The first Sunday of the new NFL season is finally upon us! While we had a little appetizer with the Bills and Rams kicking off the year Thursday, it's time for the main course today, where we can sink our teeth into a smorgasbord of bets.
As we've done in the past, we'll collect all of the best picks and gambling content each week from CBSSports.com and SportsLine and put them all in one place, so you can get picks against the spread from our CBS Sports experts as well as additional feature content for each game, including plays from top SportsLine experts and the SportsLine Projection Model, best bets from our staff, survivor picks and more.
Ready to dive in? Happy New Year!
AllNFL oddsvia Caesars Sportsbook.
Which picks can you make with confidence in Week 1? And which Super Bowl contender goes down hard?Visit SportsLine, as its incredible model simulates every NFL game 10,000 times and is up almost$7,500 for $100 players on top-rated NFL picks since its inception six years ago.
Giants at Titans
Time:Sunday, 4:25 p.m. ET (FOX), stream on fuboTV (try for free)
Open:Titans -6.5
Current:Titans -5.5
"This week, I'm backing a 'dog without high expectations after an awful year against a team that could miss the playoffs after winning the No. 1 seed last year: the New York Giants +5.5 at the Tennessee Titans.
"New coaches have done well historically against the spread in Week 1, aside from a brutal stretch in 2018-19, but rather than play that blindly, I pick my spots with the new coaches I believe are the best candidates to be long-term success stories. And I definitely feel that way about Brian Daboll, who engineered one of the league's best offenses in Buffalo and turned a divisive quarterback prospect in Josh Allen into a perennial MVP candidate. I don't think the upside is nearly as high with the offense he's inheriting in New York, but this should be a franchise on the rise after bumbling through front office and coaching mistakes over the last several years.
"The team Daboll's up against also happens to be one people are projecting to take a big step back in 2022. Elite wideout A.J. Brown is gone, replaced by the capable Robert Woods as the No. 1 option, reducing the ceiling of the passing game. The offensive line is a question mark as well, and I don't anticipate Ryan Tannehill elevating the cast around him to the heights of 2021, even with a healthy Derrick Henry in tow. And the defense could be in major trouble after losing star edge rusher Harold Landry for the year, as Bud Dupree leaves a lot to be desired as a No. 1 pass rusher. With rain expected in the forecast, this should be a lower-scoring game where the Giants can stay inside the number and potentially walk away with a win." -- R.J. White in his SuperContest picks for Week 1.
White has been SportsLine's No. 1 NFL ATS expert over the last five years, going 445-378-24 against the spread to put him up more than 25 units on those picks at SportsLine. He's also delivered a 56.8 percent hit rate on my SuperContest picks over the last seven seasons.
 Pete Prisco |  Jason La Canfora |  Will Brinson |  Jared Dubin |  Ryan Wilson |  John Breech |  Dave Richard |  Jamey Eisenberg | |
|---|---|---|---|---|---|---|---|---|
| Giants at Titans (-5.5) | Giants | Titans | Giants | Titans | Titans | Titans | Titans | Titans |
Packers at Vikings
Time:Sunday, 4:25 p.m. ET (FOX), stream on fuboTV (try for free)
Open:Packers -1.5
Current:Packers -2
"If you've ever wondered what it takes to be an MVP-caliber quarterback in the NFL, I have some good news for you: Aaron Rodgers revealed the secret this offseason. Apparently, all you have to do is have a psychedelic experience in South America. Rodgers did that this offseason and as far as I know, he is now the only NFL QB who hasobtained omnipresent, super-galactic oneness.
"If Rodgers says it works, it clearly works, because he's won two straight MVPs. Also, this would explain whyKirk Cousinshas never won an MVP. I mean, if we had to rank every NFL quarterback on the possibility that they would go on a South American psychedelic bender at some point in their life, Kirk Cousins would rank dead last.
"Although Cousins didn't do any psychedelics this offseason, I actually think he's going to be good this year. For one, he finally has a head coach who doesn't hate his guts, which seems like a positive step forward for him.
"Also, Cousins will be in charge of a high-powered offense that includesJustin JeffersonandDalvin Cook. Although I'm picking the Packers to get to the Super Bowl out of the NFC this year, I'm NOT picking them to win this game and that's because I think it's going to take a week or two for them to adjust to life withoutDavante Adams." -- CBS Sports writer extraordinaire and Pick Six Podcast super friend John Breech on why he is picking the Vikings to beat the Packers, 26-23.
Pete Prisco | Jason La Canfora | Will Brinson | Jared Dubin | Ryan Wilson | John Breech | Dave Richard | Jamey Eisenberg | |
|---|---|---|---|---|---|---|---|---|
| Packers (-1.5) at Vikings | Packers | Vikings | Packers | Packers | Packers | Vikings | Vikings | Vikings |
Chiefs at Cardinals
Time:Sunday, 4:25 p.m. ET (CBS), stream on Paramount+ (click here)
Open:Chiefs -3
Current:Chiefs -6.5
"Tom Brady skipped 11 days of training camp and Aaron Rodgers went on a South American bender, and yet, somehow, it might beKyler Murraywho had the weirdest offseason of any NFL quarterback. ... The relationship between Murray and the Cardinals feels like it's at the tipping point, and a few ugly losses to start the season could lead to a full implosion and those losses might actually happen. With theChiefs,Raidersand Rams in the first three weeks of the season, the Cardinals could be in three shootouts to start the year and they won't haveDeAndre Hopkinsfor any of those games.
"Not only do the Cardinals have to deal with all of this, but they also have to play againstPatrick Mahomes, who has never lost a regular-season opener. In four seasons as the Chiefs' starter, he's 4-0 in Week 1 and the Chiefs have scored an average of 36.25 points in those games. I would predict Kansas City to score 36.25 points on Sunday, but I'm told that's not mathematically possible in the NFL, so I'll go with 37." -- CBS Sports NFL writer and Pick Six Podcast co-host John Breech on why he likes the Chiefs to win by double digits on the road. To the read the rest of his picks, click here.
Pete Prisco | Jason La Canfora | Will Brinson | Jared Dubin | Ryan Wilson | John Breech | Dave Richard | Jamey Eisenberg | |
|---|---|---|---|---|---|---|---|---|
| Chiefs (-6) at Cardinals | Chiefs | Chiefs | Chiefs | Chiefs | Chiefs | Chiefs | Chiefs | Cardinals |
Raiders at Chargers
Time:Sunday, 4:25 p.m. ET (CBS), stream on Paramount+ (click here)
Open:Chargers -4
Current:Chargers -3.5
"The AFC West is primed to be one of the crazier divisions in the NFL this year, so why not start the year off with an upset? The Chargers have been a sexy pick to win theSuper Bowlthis season, but I believe the Raiders are catching them at a good time with prized free agent cornerJ.C. Jacksonpossibly sidelined for this game after undergoing ankle surgery earlier this summer. Going into an opener without your top corner and the task of having to defendDavante Adamsis less than ideal for Los Angeles. Pair that with Las Vegas's strong defensive line, and there's solid upset potential here.
"While Josh McDaniels' head coaching tenure with the Broncos is largely looked at as a failure, he did come out of the gate strong with a 6-0 record. Meanwhile, Chargers head coach Brandon Staley wasn't too friendly to bettors over his first season at the helm, owning an 8-9 ATS record overall and a 4-4 ATS record as a home favorite." -- Tyler Sullivan on why he is looking for the Raiders to upset the Chargers on the road.
Pete Prisco | Jason La Canfora | Will Brinson | Jared Dubin | Ryan Wilson | John Breech | Dave Richard | Jamey Eisenberg | |
|---|---|---|---|---|---|---|---|---|
| Raiders at Chargers (-3.5) | Chargers | Raiders | Raiders | Chargers | Raiders | Chargers | Chargers | Chargers |
Buccaneers at Cowboys
Time:Sunday, 8:20 p.m. ET (NBC), stream on fuboTV (try for free)
Open:Buccaneers -2.5
Current:Buccaneers -2.5
R.J. White has been a monster at picking, games and it's no surprise to learn he's SportsLine's No. 1 NFL expert. From 2017-21, he's gone 445-378-24 on his ATS picks which returned $2,542 to $100 players. White is also 33-19-4 in his NFL picks involving the Buccaneers, so you'll definitely want to see who he has in this one. We can tell you that White is leaning toward the under 50.5 total, but to see his pick for this game you'll have to have over to SportsLine.
Pete Prisco | Jason La Canfora | Will Brinson | Jared Dubin | Ryan Wilson | John Breech | Dave Richard | Jamey Eisenberg | |
|---|---|---|---|---|---|---|---|---|
| Buccaneers (-2.5) at Cowboys | Cowboys | Buccaneers | Cowboys | Buccaneers | Cowboys | Buccaneers | Buccaneers | Buccaneers |
Broncos at Seahawks
Time:Monday, 8:20 p.m. ET (ESPN, ABC), stream on fuboTV (try for free)
Open:Broncos -3.5
Current:Broncos -6.5
Josh Nagel is a Nevada-based handicapper with more than 20 years of experience in the sports wagering industry. He's also gone 17-6 on his last 23 picks involving the Seahawks, returning $1,040. We can tell you he's leaning Under the total, but he's also found a crucial X-factor on one side of the spread that you have to see. To check that out, you'll have to head over to SportsLine.
Pete Prisco | Jason La Canfora | Will Brinson | Jared Dubin | Ryan Wilson | John Breech | Dave Richard | Jamey Eisenberg | |
|---|---|---|---|---|---|---|---|---|
| Broncos (-6.5) at Seahawks | Seahawks | Broncos | Seahawks | Broncos | Broncos | Broncos | Seahawks | Broncos |
